This article explores the complexity of the spatial construction of ethnicity, identity, and sociopolitical interaction among South Sudanese ethnic groups. The article focuses on the interplay between social interaction and the construction of ethnic identity as they affect the notion of human interaction and welfare. The narratives are based on the political sociology of South Sudan after its independence from Sudan and challenges endured in the process of sociopolitical transformation towards the reconstruction of national identity and peaceful coexistence. This discourse gives meaning to visible and invisible ethno-cultural constructions that shaped the norms of social and political interactions among various ethnic groups in the country. The analysis concluded that South Sudan society is socially, politically, and culturally constructed along ethnicized communities with variant perceptions of group and regional identities based on both primordial ties and instrumentalists’ perceptions. These unique characteristics of spaces and construction of social structure has created multifaceted challenges in the process of social, economic and political reconstruction after the independent of South Sudan in July 2011.