The main objective of this study does not focus on analyzing exhaustively the urban – rural relations, but it is trying to emphasize both a theoretical interpretation and the applicability of the concept of rural-urban interface by pointing out the ways of determining the dysfunctionalities in the evolution and population structure of an administratively defined area. In order to point out these dysfunctionalities, analyses were performed at Botoşani county level, considering all the geodemographic indicators regarding the population dynamics, natural and migratory balance, and population structure. The study is based on data provided by population censuses and the statistical records of the basic territorial administrative units (communes and towns), for the period 1990‐2008. Out of these indicators only those significant for the characterization of the human potential of the urban-rural interface and for an assessment of the polarization capacity of the seven cities in the county were selected: the size of the territorial administrative unit in 2008, the population dynamics during 1990 and 2008, and the human potential standardized index. The results showed differences between the complexes(interfaces) urban-rural from the western part of the county (Botoșani, Dorohoi and Bucecea) and the Eastern one (Darabani, Săveni, Ștefănești and Flămânzi), which should promote the concept of treating the two areas (urban and rural) as a whole through the implementation of programs / projects of cooperation between local governments and various internal and external partners, the main objective being diminishing the differences (not only the demographic ones) between the two parts of the county.